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    <dc:description xml:lang="en">Tnfsf13b [tumor necrosis factor (ligand) superfamily, member 13b] mutant mice generated by the CRISPR/Cas9. 738 bp genomic fragment covering exon 1 and 2 was deleted. Deleted genomic sequence, (Chr 8:10006808 to 10007545 (GRCm38.p4))CCAAAGGCCTAGACCTTCAAAGTGCTCCTCGTGGAATGGATGAGTCTGCAAAGACCCTGCCACCACCGTGCCTCTGTTTTTGCTCCGAGAAAGGAGAAGATATGAAAGTGGGATATGATCCCATCACTCCGCAGAAGGAGGAGGGTGCCTGGTTTGGGATCTGCAGGGATGGAAGGCTGCTGGCTGCTACCCTCCTGCTGGCCCTGTTGTCCAGCAGTTTCACAGCGATGTCCTTGTACCAGTTGGCTGCCTTGCAAGCAGACCTGATGAACCTGCGCATGGAGCTGCAGAGCTACCGAGGTTCAGCAACACCAGCCGCCGCGGGTGCTCCAGAGTTGACCGCTGGAGTCAAAGTGAGTTCACCCCTCCTCTGCCTGTGCAGGAGCCCCAGGTATGCCACTCCACAGCTGTCCAGTAACGGACTGGTTGTCTCTTTTCCTAGCTCCTGACACCGGCAGCTCCTCGACCCCACAACTCCAGCCGCGGCCACAGGAACAGACGCGCTTTCCAGGGACCAGAGGAAACAGGTACGGCTGGGGCACAGCAGTTAAGAGCTGGGGCTGTGCTGTGCACACCTGCAAGCCGCCCGGCCGCGGTGAACGAAGCACTTTGTGTAGCTTTGTAGCAATTGCAATAAGCTGCGTGGCGTGCCTTGCCCTACACTGAGCAGGGTGTATGGATAGGAGGATCCCTGTGGGAGGTGACAAGACGACTAGGGTGCACGGATCTCTCGCACTG</dc:description>
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    <ns1:strainDevelopment xml:lang="en">Developed by Wataru Fujii and Yasuyuki Goto, The University of Tokyo in 2017. Fertilized eggs derived from BALB/cAJcl was used. BALB/cAJcl genetic background.</ns1:strainDevelopment>
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    <dc:description xml:lang="ja">CRISPR/Cas9 offset-nicking 法によって BAFF 遺伝子の exon1 および exon2 を含む領域 738 塩基を欠失したマウス。B細胞の応答低下。T細胞の応答性に目立った所見なし。脾臓小さめ。</dc:description>
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    <ns1:strainDevelopment xml:lang="ja">BALB/cAJcl開発者／機関：藤井渉、後藤康之/東京大学開発年：2017年BALB/cAJcl × BALB/cAJclより得られた受精卵の細胞質内にBAFFを標的とするgRNAおよびCas9 nickasemRNAを顕微注入することにより KOマウスを作出した。BALB/cAJclとの交配によってヘテロで維持する。</ns1:strainDevelopment>
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    <ns5:termsAndConditions xml:lang="ja">条件を付加する。&lt;br&gt;研究成果の公表にあたって寄託者の指定する文献を引用する。Biochem. Biophys. Res. Commun, 489(4), 528-533 (2017).</ns5:termsAndConditions>
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    <ns5:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: CRISPR/Cas9 genome edited bioresources (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/Broad_MTA_J.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/Broad_MTA_E.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;</ns5:addinfo>
    <skos:altLabel xml:lang="ja">BAFF-KO BALB/cAマウス</skos:altLabel>
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